◆ Research Business

● Efficacy Evaluation Studies

• Ophthalmic Disease Models

• Cardiovascular and Cerebrovascular Disease Models

• Immune and Inflammatory Disease Models

• Endocrine and Metabolic Disease Models

• Respiratory Disease Models

• Neurological Disease Models

• In Vivo and In Vitro Tumor Models

• Digestive System Disease Models

• Also Available: Probiotic Efficacy Evaluation, Periodontitis Model, Alveolar Bone Defect Model, Colostomy Model, etc.

1、Veterinary Drug Non-Clinical Safety Studies

• Acute Toxicity Studies

• Subchronic Toxicity Studies

• Reproductive Toxicity Studies (Traditional Teratology, Fertility Studies)

• Genotoxicity Studies (Ames, Micronucleus, Sperm Abnormality, Chromosomal Aberration)

• Chronic Toxicity Studies (Including Carcinogenicity Studies)

• Local Toxicity Studies

• Safety Pharmacology Studies

• Toxicokinetic Studies

Various Routes of Administration:

Oral, Dermal, Intradermal, Nasal, Vaginal, Inhalation, Subcutaneous, Intraperitoneal, Intramuscular, Intravenous, Intra-articular, Intraocular, Rectal, Intrathecal, Intracerebral, Intra-arterial, Intracardiac, Intrauterine, and other routes of administration

2、Veterinary Drug Clinical GCP Study Sites (Registered/Filed)

3、Open Laboratory

• Large and Small Animal Surgical Services

• Animal Biosafety Level 2 (ABSL-2) and Lower-Level Biosafety Studies

● Pharmacokinetic Evaluation Studies

Veterinary Drug Non-Clinical Pharmacokinetic Studies

In Vivo Pharmacokinetic Studies

Includes plasma concentration-time profile studies, tissue distribution studies, excretion studies (urine/bile/feces), in vivo metabolite identification, bioavailability studies, bioequivalence studies, dermal pharmacokinetic studies, ocular pharmacokinetic studies, inhalation pharmacokinetic studies, etc.

In Vitro Pharmacokinetic Studies

Includes Caco-2 cell permeability and absorption studies, plasma protein binding studies, plasma stability studies, metabolic stability studies, in vitro metabolite identification, enzyme phenotyping studies, inhibition/induction studies, transporter studies, etc.

● Clinical Testing and Evaluation Research

Sample Testing and Analysis Services

Clinical Testing and Analysis

Including but not limited to: hematology, clinical chemistry, coagulation function, coagulation factors, hemorheology, erythrocyte sedimentation rate (ESR), glycated hemoglobin (HbA1c), electrolytes, body fluids/urine, bone marrow differential cell count, etc.

Animal Pathology Testing and Analysis

Including but not limited to: HE staining, Oil Red O staining, Masson staining, PAS staining, immunohistochemistry (IHC), immunofluorescence (IF), tissue cross reactivity, etc.

Molecular Biology Testing and Analysis

Including but not limited to: cellular immunophenotyping analysis, humoral immunity analysis, neutralizing antibody analysis.

● Core Certifications/Accreditations/Qualifications

Lewwin Pharm Veterinary Drug Evaluation Research Platform has obtained international OECD GLP Certification, US FDA GLP Certification, AAALAC International Accreditation, CNAS and CNCA GLP Certifications (China National Accreditation Service for Conformity Assessment, National Certification and Accreditation Administration), and national CMA accreditation (China Metrology Accreditation), enabling global regulatory submissions.

 ◆ Veterinary Drug Testing Proficiency Certificates and Inter-Laboratory Comparisons